Detailed Product Description

Imidacloprid given orally as a single dose was moderately toxic to rats (LD50, 380650 mg/kg bw) and mice (LD50, 130170 mg/kg bw). Behavioural and respiratory signs, disturbances of motility, narrowed palpebral fissures, transient trembling and spasms were seen in rats and mice treated orally at doses > 200 mg/kg bw and > 71 mg/kg bw, respectively. The clinical signs were reversed within 6 days. Imidacloprid given intraperitoneally showed moderate to low acute toxicity in rats, the signs being similar to those after oral administration. Very little toxicity was seen after acute dermal application. The LC50 for a single exposure to an aerosol could not be determined exactly, as rats tolerated inhalation for 4 h of the maximum concentration of dust that could be produced technically (0.069 mg/l of air) without signs or deaths.